Pubblicazioni scientifiche

Link a notizie stampa
Il Resto del Carlino
La Repubblica
Malformazione di Chiari e Siringomielia
Speaker invitato a congressi:

1. VIII Congress of the Neurological and Neurosurgical italian Society (SNO). Surgery of tumors in eloquent areas. 24.01.2009, Civile Hospital, Alessandria, Italy


2. Surgery of intracranial metastases. Faculty of Medicine, University of Eastern Piedmont, Novara, 9.2.2009


3. Awake surgery for tumors in eloquent areas. Italian Society of Neurology, Cuneo, 6-7, 11. 2009


4. Up to date on rare diseases. Surgical treatment of Chiari malformation and syringomyelia. Civil Hospital,

Alessandria 08.02.2010


5. Neuroimaging of brain tumors: the neurosurgeon’s needs. Koelliker Hospital, Turin, 15.05.2010


6. Cervical Corpectomy step-by-step. In “Cadaver lab of cervical spine approaches”. Department of Anatomy, University of Wien, Austria, 15-17-02.2011


7. Awake Brain Surgery: from surgery to research. University of Turin, 14.06.2013


8. Chiari syndrome and syringomyelia. Clinical and surgical aspects. Domus Salutis, Brescia, 15.05.2013


9. Awake surgery and intraoperative mapping: neurooncological usefulness and model for brain functions study. Lecture at the Physiology PhD school, University of Milan, 25.05.2013


10. Glioblastoma: up to date on novel therapies. University of Milan, 15.04.2014


11. Surgical approaches to the lumbar spondilolysthesise: PLF, PLIF, TLIF. how we do in Brescia. Spine section of SINCH, Catania, 5-6-7.06.2014


12. Spinal Intramedullary tumors. In “Management strategies and surgical techniques in spine surgery:

avoid and prevent failures”. Ferrara, 12.12.2014


13. DTI challenge. Italian chapter of the ISMRM. Verona, 16-17.04.2015


14. Cerebello-pontine angle tumors: evolution of the surgical approaches related to new treatment’s paradigms. SPIGC (Italian Society of Young Surgeons), Brescia, 11-13 june 2015


15. VII° Incontro Convegno 10 – 11 – 12 aprile 2015 dell'ACAR (associazione  per malattia esostosante e sulla sindrome di Ollier/Maffucci). Tema: Gliomi cerebrali e malattia di Ollier


16.Supratentorial gliomas in eloquent areas: which parameters can predict extent of resection and functional outcome. Neurooncology updates, 14th edition, Cortona, 1-3 july 2015


16. Supratentorial gliomas in eloquent areas: Can we predict extent of resection and functional outcome? EANS annual meeting 2015, 18-21 October, Madrid


17. Anniversario 10 anni dell'AISMAC (associazione italiana siringomielia e malattia di Arnold-Chiari).


18. Approcci laterali al basicranio medio e posteriore. 10-12 marzo 2016, Torino

19. Indicazioni al trattamento chirurgico negli ematomi intracerebrali. “Gestione delle Urgenze in Neurochirurgia”, Fondazione Policlinico IRCCS, Milano, 05.12.2016

20. Far lateral approach and extended pterional approach. 54th W. Laugheed Microsurgical Course, Western Hospital and University of Toronto, Canada. 1-5 Maggio 2017

21. Gliomi Cerebrali: strategie terapeutiche combinate. 25 e 26 Maggio 2017. Venezia

22. CSF dynamics alterations: the challenge of Chiari Malformation. In: Focus on Cerebrospinal Fluid, from basic to clinical research. 6 Ottobre 2017, Franciacorta-Brescia

23. Tumori cerebrali sopratentoriali. In: Gestione del bambino con tumore cerebrale, Ospedale San Gerardo di Monza, 18.11.2017

24. Multimodal management of complex ruptured cerebellar AVM. Masterclass at EANS 2018, Brussels

25. Which approach for giant trigeminal schwannoma? Masterclass at EANS 2018, Brussels

26. TRATTAMENTI INTEGRATI CHIRURGIA-RADIOCHIRURGIA: È GIUNTO IL TEMPO DELL’HYBRID SURGERY? Congresso celebrativo dei 10 anni della gamma knife Niguarda. Novembre 2018


 ttp://www.ncbi.nlm.n !


1. Bonioli E, Hennekam RC, Spena G, Morcaldi G, Di Stefano A, Serra G, Bellini C.
Aplasia cutis congenita, skull defect, brain heterotopia, and intestinal lymphangiectasia. Am J Med Genet. Jan 15;132(2):202-5, 2005

2. Spena G, Gatignol P, Capelle L, Duffau H. Superior longitudinal fsciculus subserves vestibular network in humans. Neuroreport Sep 18;17(13): 1403-6, 2006

3. Zona G, Spena G, Sbaffi PF, Spaziante R. A meningioma with islets of extramedullary myeloid metaplasia: case report. Neurosurgery Aug; 61(2): 418-9, 2007

4. Spena G, Fasel J, De Tribolet N, Radovanovic I. Subfrontal endoscopic fenestration of lamina terminalis: an anatomical study. Minimally Invasive Neurosurgery, 6 vol 51, 313-374, 2008

5. Spena G, Bernucci C, Garbossa D, Valfrè V, Versari P. Clinical and radiological outcome of craniocervical osteo-dural decompression for Chiari I-associated s!yringomyelia. Neurosurgical Review, DOI 10.1007/s10143-010-0260-y

6. Spena G, Garbossa D, Barletta L, Prevost C, Versari P. Preoperative chemotherapy for infiltrative low-grade oligoastrocytoma: a useful strategy o maximize surgic!al resection. Neurol Med Chir (Tokio) 50, 408-411, 2010

8. Szelényi A, Bello L, Duffau H, Fava E, Feigl GC, Galanda M, Neuloh G, Signorelli F, Sala F.
Intraoperative electrical stimulation in awake craniotomy: methodological aspects of current practice. Workgroup for Intraoperative Management in Low-Grade Glioma Surgery within the European Low-Grade Glioma Network. Neurosurg Focus. 2010 Feb;28(2):E7. doi: 10.3171/2009.12.FOCUS09237. Review.

9. Spena G, Nava A, Cassini F, Pepoli A, Bruno M, D'Agata F, Cauda F, Sacco K, Duca S, Barletta L, Versari P. Preoperative and intraoperative brain mapping for the resection of eloquent-area tumors. A prospective analysis of methodology, correlation, and usefulness based on clinical outcomes. Acta Neurochir (Wien). 2010 Nov;152(11):1835-46.

10. Spena G, Versari P. Bubbles in the head: a new method for brain retraction during craniotomy. Acta Neurochir (Wien). 2011 Sep;153(9):1807-11.

11. Comment on “Long-term outcome of surgical management of adult Chiari I malformation”. El-Ghandour N. Neurosurg Rev 2012; 35:537-547

12. Comment on “The endoscopic endonasal approach for the management of craniopharyngioms involving the third ventricle. Cavallo LM, Solari D, Esposito F, Cappabianca. Neurosurg Rev 2013;36(2):340

13. Comment on “Less invasive transjugular approach with Fallopian bridge technique for facial nerve protection and hearing preservation in surgery of gloms jugular tumors. Nonaka Y, Fukushima T, Watanabe K, Friedman AH, McElveen JT, Cunningham CD, Zomorodi AR. Neurosurg Rev 2013; 36(4):579-86

14. Spena G, Garbossa D, Panciani PP, Griva F, Fontanella MM. Purely subcortical tumors in eloquent areas: Awake surgery and cortical and subcortical electrical stimulation (CSES) ensure safe and effective surgery. Clin Neurol Neurosurg. 2013 Mar 2.

15. Garbossa D, Panciani PP, Angeleri R, Battaglia L, Tartara F, Ajello M, Agnoletti A, Versari P, Ducati A, Fontanella M, Spena G. A retrospective two-center study of antiepileptic prophylaxis in patients with surgically treated high-grade gliomas. Neurol India. 2013 Mar-Apr;61(2):131-7

16. Beez T, Boge K, Wager M, Whittle I, Fontaine D, Spena G, Braun S, Szelényi A, Bello L, Duffau H, Sabel M; European Low Grade Glioma Network. Tolerance of awake surgery for glioma: a prospective European Low Grade Glioma Network multicenter study. Acta Neurochir (Wien). 2013 Jul;155(7):1301-8.doi: 10.1007/s00701-013-1759-0.

17. Nicolosi F, Nodari G, Spena G, Roca E, Migliorati K, Esposito G, Stefini R, Fontanella M, Panciani PP. Cerebral Wegener's granuloma: surgery mandatory for diagnosis and treatment. Case Rep Neurol Med. 2013;2013:750391. doi: 10.1155/2013/750391.

18. Comment on “Posterior condylar canals and posterior condylar emissary veins- a microsurgical and CT anatomical study. Matsushima K, Kawashima M, Matsushima T, Hiraishi T, Noguchi T, Kuraoka A. Neurosurg Rev 2014; 37(1): 115-126

19. Fontanella M, Benevello C, Panciani PP, Ronchetti G, Bacigaluppi S, Stefini R, Spena G, Garbossa D, Ducati A. Automated end-to-side anastomosis to the middle cerebral artery with C-Port xA: A feasibility study on human cadavers. Asian J Neurosurg. 2013 Apr;8(2):74-7. doi: 10.4103/1793-5482.116377

20. Crobeddu E, Panciani PP, Garbossa D, Pilloni G, Fornaro R, Ronchetti G, Spena G, Tartara F, Ducati A, Fontanella M. Cerebrovascular diseases in the elderly: the challenge of multiple aneurysms. Int J Neurosci. 2014 Aug;124(8):573-6

21. Spena G, D'Agata F, Panciani PP, Buglione di Monale M, Fontanella MM. Supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection? PLoS One. 2013 Dec 5;8(12):e80916

22. Ronchetti G, Panciani PP, Stefini R, Spena G, Fontanella MM. Acute supratentorial ischemic stroke: when surgery is mandatory. Biomed Res Int. 2014;2014:624126

23. Fontanella MM, Panciani PP, Spena G, Roca E, Migliorati K, Ambrosi C, Sturiale CL, Retta FS. Professional athletes and cerebral cavernomas: an obstacle to overcome. J Sports Med Phys Fitness. 2014 Mar 18

24. Tardivo V, Crobeddu E, Pilloni G, Fontanella M, Spena G, Panciani PP, Berjano P, Ajello M, Bozzaro M, Agnoletti A, Altieri R, Fiumefreddo A, Zenga F, Ducati A, Garbossa D. Say "no" to spinal cord injury: is nitric oxide an option for therapeutic strategies? Int J Neurosci. 2014 May 27

25. Aneurismal bone cysts. Commentary. Spena G. J Neurosci Rural Pract. 2014 Jan;5(1):58. No abstract available.

26. Agnoletti A, Mencarani C, Panciani PP, Buffoni L, Ronchetti G, Spena G, Tartara F, Buglione M, Pagano M, Ducati A, Fontanella M, Garbossa D. Surgery in cerebral metastases: are numbers so important? J Cancer Res Ther. 2014 Jan-Mar;10(1):79-83

27. Spena G, Costi E, Panciani PP, Roca E, Migliorati K, Fontanella MM. Acute functional reactivation of the language network during awake intraoperative brain mapping. Neurocase. 2014 May 7:1-5

28. Buglione M, Spiazzi L, Saiani F, Costa L, Shehi B, Lazzari B, Uccelli C, Pasinetti N, Borghetti P, Triggini L, Donadoni L, Pedretti S, Magrini SM; Neuro-Oncology Group, Spedali Civili, Brescia University, Brescia, Italy. Three-dimensional conformal radiotherapy, static intensity-modulated and helical intensity-modulated radiotherapy in glioblastoma. Dosimetric comparison in patients with overlap between target volumes and organs at risk. Tumori. 2014 May-Jun;100(3):272-7

29. Spena G, Panciani PP, Fontanella MM. Resection of supratentorial gliomas: the need to merge microsurgical technical cornerstones with modern functional mapping concepts. An overview. Neurosurg Rev. 2014 Oct 21

30. Fontanella MM, Fazio M, Francione A, Bacigaluppi S, Griva F, Visocchi M, Panciani PP, Bergomi R, Spena G. Pre-symptomatic cervical myelopathy: should we operate or should we observe? What is the chance of spinal cord injury from an accident? J Neurosurg Sci. 2014 Jun;58(2 Suppl 1):15-22

31. Spena G, Panciani PP, Costi E, Nicolosi F, Fontanella MM. Minimally invasive surgery for thoracic and lumbar spinal fractures: rationale for treatment. J Neurosurg Sci. 2014 Jun;58(2 Suppl 1):23-7

32. Ajello M, Garbossa D, Fiumefreddo A, Marengo N, Bozzaro M, Tartara F, Zenga F, Pilloni G, Panciani PP, Spena G, Berjano P, Fontanella M, Ducati A. Do stand alone cervical interbody spacers pose any advantage over plate and screws? J Neurosurg Sci. 2014 Jun;58(2 Suppl 1):49-53

33. Crobeddu E, Garbossa D, Pilloni G, Bozzaro M, Berjano P, Gontero P, Fiorito C, Panciani PP, Spena G, Zenga F, Tartara F, Fontanella M, Ducati A. Management of vascular and ureteral complications after lumbar discectomy. J Neurosurg Sci. 2014 Jun;58(2 Suppl 1):107-12.

34. Bacigaluppi S, Zona G, Secci F, Spena G, Mavilio N, Brusa G, Agid R, Krings T, Ottonello G, Fontanella M. Diagnosis of cerebral vasospasm and risk of delayed cerebral ischemia related to aneurysmal subarachnoid haemorrhage: an overview of available tools. Neurosurg Rev. 2015 Mar 4

35. Stefini R, Zenga F, Esposito G, Bolzoni A, Tartara F, Spena G, Ambrosi C, Fontanella MM. Following the canyon to reach and remove olfactory groove meningiomas: surgical experience. J Neurosurg Sci. 2015 Mar 10

36. Buglione M, Borghetti P, Pedretti S, Triggiani L, Fontanella MM, Spena G, Grisanti S, Liserre R, Poliani LP, Gipponi S, Spiazzi L, Magrini SM. Post-surgical therapeutic approaches to glioblastoma patients submitted to biopsy (BA) or "partial" resection (PR): the possibilities to treat also them without renunciations. Study from the Brescia Neuro-Oncology Group. Radiol Med. 2015 Mar 15

37. Rofes A, Spena G, Miozzo A, Fontanella M, Miceli G. Advantages and disadvantages of intraoperative languages tasks in awake surgery: a three-task approach for prefrontal tumors. J Neurosurg Sci 2015 Jul 10

38. Altieri R, Fontanella M, Agnoletti A, Panciani PP, Spena G, Crobeddu E, Pilloni G, Tardivo V, Lanotte M, Zenga F, Ducati A, Garbossa D.Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?Transl Med UniSa. 2014 Sep 1;12:54-9

39. Altieri R, Zenga F, Fontanella MM, Cofano F, Agnoletti A, Spena G, Crobeddu E, Fornaro R, Ducati A, Garbossa D.Glioma Surgery: Technological Advances to Achieve a Maximal Safe Resection.Surg Technol Int. 2015 Nov;27:297-302

40. Buglione M, Pedretti S, Poliani PL, Liserre R, Gipponi S, Spena G, Borghetti P, Pegurri L, Saiani F, Spiazzi L, Tesini G, Uccelli C, Triggiani L, Magrini SM.Pattern of relapse of glioblastoma multiforme treated with radical radio-chemotherapy: could a margin reduction be proposed.J Neurooncol. 2016 Mar 30

41. Spena G, Schucht P, Seidel K, Rutten GJ, Freyschlag CF, D'Agata F, Costi E, Zappa F, Fontanella M, Fontaine D, Almairac F, Cavallo M, De Bonis P, Conesa G, Foroglou N, Gil-Robles S, Mandonnet E, Martino J, Picht T, Viegas C, Wager M, Pallud J. Brain tumors in eloquent areas: A European multicenter survey of intraoperative mapping techniques, intraoperative seizures occurrence, and antiepileptic drug prophylaxis. Neurosurg Rev. 2016 Aug 1

42. Bertuccio A, Robba C, Spena G, Versari PP.Intracranial and Spinal Dural Arterio-Venous Fistula (DAVF): A Surgical Series of 107 Patients.Acta Neurochir Suppl. 2016;123:177-83. doi: 10.1007/978-3-319-29887-0_25

43. Grisanti S, Ferrari VD, Buglione M, Agazzi GM, Liserre R, Poliani L, Buttolo L, Gipponi S, Pedersini R, Consoli F, Panciani P, Roca E, Spena G, Triggiani L, Berruti A; Gruppo Neuro-Oncologico Bresciano.Second line treatment of recurrent glioblastoma with sunitinib: results of a phase II study and systematic review of literature.J Neurosurg Sci. 2016 Sep 28

44. Rofes A, Spena G, Talacchi A, Santini B, Miozzo A, Miceli G. Mapping nouns and finite verbs in left hemisphere tumors: a direct electrical stimulation study. Neurocase. 2017 Mar 27:1-9. 

45. Rofes A, Mandonnet E, Godden J, Baron MH, Colle H, Darlix A, de Aguiar V, Duffau H, Herbet G, Klein M, Lubrano V, Martino J, Mathew R, Miceli G, Moritz-Gasser S, Pallud J, Papagno C, Rech F, Robert E, Rutten GJ, Santarius T, Satoer D, Sierpowska J, Smits A, Skrap M, Spena G, Visch E, De Witte E, Zetterling M, Wager M.  Survey on current cognitive practices within the European Low-Grade Glioma Network: towards a European assessment protocol. Acta Neurochir (Wien). 2017 May 4. doi: 10.1007/s00701-017-3192-2

47. Pallud J, Mandonnet E, Corns R, Dezamis E, Parraga E, Zanello M, Spena G. Technical principles of direct bipolar electrostimulation for cortical and subcortical mapping in awake craniotomy. Neurochirurgie. 2017 May 12. pii: S0028-3770(17)30035-8.

48. Altieri R, Hirono S, Duffau H, Ducati A, Fontanella M, LA Rocca G, Melcarne A, Panciani PP, Spena G, Garbossa D.

49. Mandonnet E, Anract P, Martin E, Roujeau T, Spena G, Cormier-Daire V, Duffau H, Baujat G; Collaborators. Brain and skull base MRI findings in patients with Ollier-Maffucci disease: A series of 12 patient-cases. Mandonnet E, Anract P, Martin E, Roujeau T, Spena G, Cormier-Daire V, Duffau H, Baujat G; Collaborators.Clin Neurol Neurosurg. 2017 Sep;160:147-151

50. Spena G, Sorrentino T, Altieri R, Redaelli de Zinis L, Stefani R, Panciani PP, Fontanella M. Early career surgical practice for cerebello-pontine angle tumors in the era of radiosurgery. J of Neurological Surgery-Part B. DOI:10.1055/s-0037-1606826

51. Spena G, D’Agata F, Panciani P, Buttalo L, Buglione di Monale Bastia M, Fontanella M. Practical prognostic score for predicting the extent of resection and neurological outcome of gliomas in the sensorimotor area. Clinical Neurology and Neurosurgery 2018 Jan;164:25-31. doi: 10.1016/j.clineuro.2017.11.009

 52. Panciani PP, Giordana MT, Gallone S, Muratori A, Rotunno R, Migliorati K, Spena G, Ducati A, Fontanella M. Blood-tissue analysis of TP53 polymorphisms and survival of patients with glioma. J Neurosurg Sci. 2018 Jan 4. doi: 10.23736/S0390-5616.18.04284-4

53. Spena G, Sorrentino T, Altieri R, Zinis LR, Stefini R, Panciani PP, Fontanella M. Early-Career Surgical Practice for Cerebellopontine Angle Tumors in the Era of Radiosurgery. J Neurol Surg B Skull Base. 2018 Jun;79(3):269-281. doi: 10.1055/s-0037-1606826

54. Spena G. Letter: A Method for Cranial Nerve XI Silencing During Surgery of the Foramen Magnum Region: Technical Case Report. Oper Neurosurg (Hagerstown). 2019 Jan 1;16(1):E35. doi: 10.1093/ons/opy315

55. Doglietto F, Belotti F, Nucci CG, Roca E, Mattogno PP, Zappa F, Migliorati K, Panciani PP, Spena G, Cereda C, Cornali C, Fontanella MM. Three-Dimensional High-Definition Ventriculoscope: Single-Center Case Series. World Neurosurg. 2019 Feb 11. pii: S1878-8750(19)30331-6. doi: 10.1016/j.wneu.2019.01.219

56. Zanello M, Goodden JR, Colle H, Wager M, Hamer PCW, Smits A, Bello L, Tate M, Spena G, Bresson D, Capelle L, Robles SG, Sarubbo S, Rydenhag B, Martino J, Meyer B, Fontaine D, Reyns N, Schichor C, Metellus P, Colle D, Robert E, Noens B, Muller P, Rossi M, Nibali MC, Papagno C, Galbarritu L, de Gopegui ER, Chioffi F, Bucheli C, Krieg SM, Wostrack M, Yusupov N, Visser V, Baaijen JC, Roux A, Dezamis E, Mandonnet E, Corns R, Duffau H, Pallud J. Predictors of Epileptic Seizures and Ability to Work in Supratentorial Cavernous Angioma Located Within Eloquent Brain Areas. Neurosurgery. 2019 Mar 29. pii: nyz063. doi: 10.1093/neuros/nyz063

57. Guerrini F, Roca E, Verlotta M, Grimod G, Spena G. When a benign disease turns into disaster: a unique case of a surgically treated hemorrhagic sylvian fissure meningioma. J Neurosurg Sci. 2019 Apr 2. doi: 10.23736/S0390-5616.19.04689-7

58. Zanello M, Meyer B, Still M, Goodden JR, Colle H, Schichor C, Bello L, Wager M, Smits A, Rydenhag B, Tate M, Metellus P, Hamer PW, Spena G, Capelle L, Mandonnet E, Robles SG, Sarubbo S, Martino González J, Fontaine D, Reyns N, Krieg SM, Huberfeld G, Wostrack M, Colle D, Robert E, Noens B, Muller P, Yusupov N, Rossi M, Conti Nibali M, Papagno C, Visser V, Baaijen H, Galbarritu L, Chioffi F, Bucheli C, Roux A, Dezamis E, Duffau H, Pallud J. Surgical resection of cavernous angioma located within eloquent brain areas: International survey of the practical management among 19 specialized centers.

Seizure. 2019 Mar 28;69:31-40. doi: 10.1016/j.seizure.2019.03.022

59. Spena G, Guerrini F, Grimod G, Salmaggi A, Mazzeo LA. Polymethyl Methacrylate Cranioplasty Is an Effective Ultrasound Window to Explore Intracranial Structures: Preliminary Experience and Future Perspectives. World Neurosurg. 2019 Apr 8. pii: S1878-8750(19)31018-6. doi: 10.1016/j.wneu.2019.04.026

60. Spena G, Guerrini F, Decet P, D'agata F, Roca E, Belotti F, Nucci CG, Fontanella MM. Are convexity meningiomas all the same? A clinico-radiological analysis of surgically treated eloquent areas convexity meningiomas. J Neurosurg Sci. 2019 Jul 11. doi: 10.23736/S0390-5616.19.04713-1





1. Trattamento chirurgico: derivazione ventricolo-peritoneale e ventricolo-atriale. 

In Idrocefalo normoteso I edizione (2016) PANCIANI P. P., FONTANELLA M. M.
ISBN-13 978-88-7711-863-9
Lingua: Italiano

2. Multimodal Approach to the Surgical Removal of Gliomas in Eloquent Brain Regions. Giannantonio Spena, Antonio Pepoli, Marcella Bruno, Federico D’Agata, Franco Cauda, Katiuscia Sacco, Sergio Duca and Pietro Versari (2011). In  Advances in the Biology, Imaging and Therapies for Glioblastoma, Prof. Clark Chen
(Ed.), ISBN: 978-953-307-284-5, InTech, DOI: 10.5772/24446. Available from: http://www.intechopen.- com/books/advances-in-the-biology-imaging-and-therapies-for-glioblastoma/multimodal-approach-to-thesurgical- removal-of-gliomas-in-eloquent-brain-regions

Management of Chiari Malformation. In “Surgery of the Cranio-Vertebral Junction”, Tessitore/Dehdashti/Schonauer/Thome. Springer, In press